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Boris Draznin Selected Research

Phosphatidylinositol 3-Kinases (PI 3 Kinase)

3/2009Rescuing 3T3-L1 adipocytes from insulin resistance induced by stimulation of Akt-mammalian target of rapamycin/p70 S6 kinase (S6K1) pathway and serine phosphorylation of insulin receptor substrate-1: effect of reduced expression of p85alpha subunit of phosphatidylinositol 3-kinase and S6K1 kinase.
11/2007Insulin attenuates vascular smooth muscle calcification but increases vascular smooth muscle cell phosphate transport.
6/2007Growth hormone regulation of p85alpha expression and phosphoinositide 3-kinase activity in adipose tissue: mechanism for growth hormone-mediated insulin resistance.
4/2006Early growth response gene-1 expression in vascular smooth muscle cells effects of insulin and oxidant stress.
11/2005Increased P85alpha is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess.
8/2004Insulin regulation of sterol regulatory element-binding protein-1 expression in L-6 muscle cells and 3T3 L1 adipocytes.
10/2003Insulin affects vascular smooth muscle cell phenotype and migration via distinct signaling pathways.
1/2002Phosphatidylinositol 3-kinase redistribution is associated with skeletal muscle insulin resistance in gestational diabetes mellitus.

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Boris Draznin Research Topics

Disease

20Insulin Resistance
04/2013 - 01/2002
9Hyperinsulinism (Hyperinsulinemia)
06/2011 - 01/2002
7Type 2 Diabetes Mellitus (MODY)
12/2016 - 07/2006
5Hyperglycemia
12/2016 - 09/2012
5Obesity
04/2013 - 07/2006
3Hypoglycemia (Reactive Hypoglycemia)
01/2020 - 12/2011
3Infections
12/2016 - 09/2012
3Atherosclerosis
06/2011 - 12/2005
3Neoplasms (Cancer)
06/2011 - 12/2003
2Cardiovascular Diseases (Cardiovascular Disease)
03/2017 - 04/2008
2Diabetes Mellitus
03/2017 - 02/2014
2Pulmonary Embolism
12/2016 - 12/2014
2Venous Thrombosis (Deep-Vein Thrombosis)
12/2016 - 12/2014
2Critical Illness (Critically Ill)
10/2015 - 12/2011
2Metabolic Syndrome (Dysmetabolic Syndrome X)
07/2013 - 04/2008
2Body Weight (Weight, Body)
09/2012 - 04/2005
2Mitochondrial Diseases (Mitochondrial Disease)
01/2009 - 08/2006
1Myocardial Infarction
03/2017
1Cross Infection (Nosocomial Infection)
12/2016
1Hashimoto's encephalitis
12/2014
1Type 1 Diabetes Mellitus (Autoimmune Diabetes)
12/2014
1Chronic Kidney Failure (Chronic Renal Failure)
04/2013
1Diabetic Ketoacidosis (Ketoacidosis, Diabetic)
09/2012
1Multiple Abnormalities
02/2010
1Dyslipidemias (Dyslipidemia)
02/2010
1Hypertension (High Blood Pressure)
02/2010
1Inflammation (Inflammations)
10/2009
1Overnutrition
09/2009
1Weight Loss (Weight Reduction)
04/2008
1Hypoadiponectinemia
06/2007
1Hypersensitivity (Allergy)
06/2007
1Growth hormone excess
11/2005

Drug/Important Bio-Agent (IBA)

22Insulin (Novolin)FDA Link
01/2020 - 01/2002
8Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA
03/2009 - 01/2002
6Glucose (Dextrose)FDA LinkGeneric
12/2016 - 03/2002
4Phosphotransferases (Kinase)IBA
03/2009 - 08/2004
4Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
03/2009 - 01/2002
4Growth Hormone (Somatotropin)IBA
06/2007 - 03/2002
3Blood Glucose (Blood Sugar)IBA
12/2016 - 09/2012
3GlucocorticoidsIBA
02/2016 - 04/2013
3Insulin Glargine (Lantus)FDA Link
06/2014 - 12/2011
3Proteins (Proteins, Gene)FDA Link
07/2006 - 03/2004
2Hemoglobins (Hemoglobin)IBA
03/2017 - 12/2016
2CreatinineIBA
12/2016 - 12/2014
2Dietary Fats (Dietary Fat)IBA
01/2012 - 04/2008
2LipidsIBA
10/2009 - 04/2005
2Serine (L-Serine)FDA Link
03/2009 - 08/2006
2Insulin Receptor Substrate ProteinsIBA
03/2009 - 08/2006
2Insulin ReceptorIBA
12/2003 - 01/2002
1Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA
03/2017
1Angiotensin Receptor AntagonistsIBA
03/2017
1Calcium Channel Blockers (Blockers, Calcium Channel)IBA
03/2017
1Isophane Insulin (NPH Insulin)FDA Link
02/2016
1SteroidsIBA
12/2014
1MethylprednisoloneFDA LinkGeneric
12/2014
1Intravenous Immunoglobulins (IVIG)FDA Link
12/2014
1Long-Acting Insulin (Insulin, Long Acting)FDA Link
09/2012
1Insulin Lispro (Humalog)FDA Link
12/2011
1Biphasic InsulinsIBA
12/2011
1ras ProteinsIBA
06/2011
1EnzymesIBA
06/2011
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
06/2011
1Farnesyltranstransferase (Farnesyltransferase)IBA
06/2011
1SugarsIBA
02/2010
1Coconut OilIBA
02/2010
1High Fructose Corn SyrupIBA
02/2010
1Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA
02/2010
1Biomarkers (Surrogate Marker)IBA
10/2009
1Oxygen (Dioxygen)IBA
10/2009
1Interleukin-6 (Interleukin 6)IBA
10/2009
1C-Reactive ProteinIBA
10/2009
1Small Interfering RNA (siRNA)IBA
03/2009
1TOR Serine-Threonine KinasesIBA
03/2009
170-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)IBA
03/2009
1Cyanides (Isocyanides)IBA
01/2009
1HydrazonesIBA
01/2009
1Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone (FCCP)IBA
01/2009
1Dietary Carbohydrates (Carbohydrate, Dietary)IBA
04/2008
1CarbohydratesIBA
04/2008
1Phosphatidylinositols (Phosphatidylinositol)IBA
06/2007
1Triglycerides (Triacylglycerol)IBA
07/2006
1Messenger RNA (mRNA)IBA
07/2006
1Sterol Regulatory Element Binding Protein 1IBA
07/2006
1Oxidants (Oxidizing Agents)IBA
04/2006
1AdiponectinIBA
12/2005
1Hormones (Hormone)IBA
11/2005
1Placental HormonesIBA
03/2004
1Proto-Oncogene Proteins p21(ras)IBA
12/2003

Therapy/Procedure

6Glycemic Control
12/2016 - 12/2011
3Therapeutics
09/2012 - 12/2011
2Parenteral Nutrition
12/2016 - 12/2014
2Enteral Nutrition (Feeding, Tube)
04/2013 - 12/2011
1Off-Label Use
10/2015
1Length of Stay
12/2014
1Transitional Care
02/2014
1Caloric Restriction
04/2013
1Peritoneal Dialysis
04/2013
1Organ Transplantation
09/2012
1Carbohydrate-Restricted Diet (Low Carbohydrate Diet)
04/2008
1Fat-Restricted Diet (Diet, Fat Restricted)
04/2008